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All-Pay-All Auctions

We consider a class of auctions in which bidders receive (asymmetric) shares of the amount of money raised. Examples include corporate takeovers when potential acquirers have “toeholds” and auctions used to raise money for a public good. We show that the optimal selling mechanism in these cases is a simple “all-pay-all” auction in which all bidders pay a weighted sum of all bids. When bidders r...

All - Against - All Sequence

In this paper we present an algorithm which attempts to align pairs of subsequences from a database of DNA sequences. The algorithm simulates the classical dynamic programming alignment algorithm over a digital index of the database. The running time of the algorithm is subquadratic on average with respect to the database size. A similar algorithm solves the approximate string matching problem ...

All for All

I n this small and charming book, Won for All, Michael Ashburner gives us a glittering account of the sequencing of the Drosophila genome by a public–private partnership between government-funded laboratories and Celera Genomics. He portrays both the working life and the good life of science, with neat character sketches set off by Lewis Miller's excellent portraits. Michael's fl air for detail...

Integrated Care: A Pill for All Ills?

There is an increasing policy emphasis on the integration of care, both within the healthcare sector and also between the health and social care sectors, with the simple aim of ensuring that individuals get the right care, in the right place, at the right time. However, implementing this simple aim is rather more complex. In this editorial, we seek to make sense of this complexity and ask: what...

Ring With All Finitely Generated Modules Retractable

All Things to All People

Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.